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Key: test item, instrument name, total nonvolatile migration, gravimeter, moisture permeameter

Product

Determination of Overall Migration Constant Weight Analyzer

ERT-231 /462 -B
Focusing on packaging and material testing technology, we are committed to quality control in industries such as healthcare, pharmaceuticals, food, packaging, textiles, and new materials. Our products are widely used in enterprises, testing institutions, universities, and research institutes.

Category:

Product Center

Constant Weight Analyzer

Water Bath Drying Constant Weight

Automated Constant Weight Workstation — ETR Series

Functions

Perform constant weight tests for loss on drying, non-volatile substances, residue quantity, total migration, volatile substances, moisture content, and soluble/insoluble quantities.

Replace traditional workflows — consolidate water baths, drying ovens, desiccators, and analytical balances into a single automated system.

Eliminate manual sample transfers, reduce human error, and accelerate quality control for pharmaceutical, food, chemical, and polymer laboratories.

Working Principle

The ETR Series integrates four critical processes into one enclosed unit: water bath evaporation, high-temperature drying, controlled cooling, and precision weighing.

Evaporation: Samples in evaporating utensils are heated via a water bath (RT ~ 100 °C) to remove volatile solvents.

Drying: The chamber temperature rises to 140 °C to drive off bound moisture and volatile matter.

Cooling: Samples are cooled in a controlled-humidity environment (< 20 % RH) to prevent moisture reabsorption.

Weighing: A METTLER TOLEDO analytical balance (0.1mg readability, optional 0.01mg) performs automated weighing. The system repeats drying-cooling-weighing cycles until constant weight (0.3 mg variation over 2 cycles) is achieved.

All steps are controlled by professional software with programmable parameters, real-time monitoring, and automatic data logging.

Compliant Standards

USP <921> — Loss on Drying(United States Pharmacopeia)

EP 2.2.32 — Loss on Drying(European Pharmacopoeia)

ISO 759 — Plastics — Determination of loss of volatile matter

ISO 17025 — General requirements for the competence of testing and calibration laboratories

ChP 2025 — General Chapters: Loss on Drying, Total Solids, Extractives Determination

YBB 00342002 / YBB 00132002 — Pharmaceutical packaging materials test methods

GB 31604.8 — Food contact materials — Total migration

GB 5009.3 — National food safety standard — Determination of moisture

GB/T 9740 / GB/T 2914 — Chemical product loss on drying

Key Features

Fully Automated 4-Step Process: Water bath → Drying → Cooling → Weighing. No manual intervention required after sample loading.

Ultra-High Precision: Achieves 0.3 mg constant weight in just 2 drying cycles using a METTLER TOLEDO balance (210 g capacity, 0.1 mg readability; 0.01 mg optional).

Scalable Throughput: Available in 12, 18, 23, 33, 46, or 69 workstation configurations to match any lab's daily volume.

Patented Balance Protection: Proprietary heat insulation, moisture-proof, and anti-corrosion technology shields the balance from thermal drift and chemical attack, ensuring long-term stability and extended service life.

Indirect Heating Design: Prevents combustion and explosion risks. Equipped with over-temperature power-off and water-level protection for safe operation.

Compact Integration: Combines water bath chamber, drying oven, cooling unit, and balance into a single footprint — saves valuable lab bench space.

Dual Test Modes: Constant Weight Mode (auto-terminates at stable mass) and Constant Time Mode (fixed drying duration).

Professional Software: Graphical, full-process monitoring with real-time curves, multi-factor data logging, and customizable report formats.

GMP-Ready (Optional): Optional Computerized System module adds user management, access control, and audit trail for 21 CFR Part 11 compliance.

Solvent Recovery (Optional): High-efficiency recovery unit captures up to 95 % of evaporated solvents, reducing hazardous waste disposal costs and VOC emissions.

Technical Specifications

Name	Parameter	Name		Parameter
Constant Weighing Error	0.3 mg,（2 heating cycles）	Residue Range		0 ∼ 80g
Balance Range	210 g	Balance Readability		0.1mg
Temperature Error	0.5 ℃	Evaporation Temperature		RT ∼ 100 ℃
Drying Temperature	RT∼140 ℃	Weighing Temperature		RT ∼ 80 ℃
Evaporation Mode	Water bath	Weighing humidity		＜20%
Evaporating utensil capacity	100 mL (Optional: 50, 200 mL)	Connection Pipe		Φ8 mm
Air Pressure	>0.3 MPa	Solvent Recovery Rate		Up to 95% (with optional unit)
Power Supply	AC220V /110V ;50/60Hz
Model	Model No
	ERT-231-B		ERT-462-B
Specimen Capacity	23		46
Balance Quantity	1		2
Dimensions	1300x870x1160 mm(LBH)
Net Weight	≈ 175kg		≈ 185kg
Power Consumption	<10,000 W

Configuration: Principal Machine, Dryer Machine, Evaporating Utensil, Computer, Professional software, Valve Suits.

Optional: Solvent Recovery Machine、0.01mg balance.

Self-provided: Compressed air、Distilled water, tap water.

Application Industries & Scenarios

Pharmaceutical Industry

Loss on Drying & Moisture Content: Raw material QC per USP <921> and ChP.

Total Migration & Extractables: Packaging material safety studies per YBB and EP.

Stability Testing: Generate ICH Q1A/Q1B support data for drug substance and product registration.

GMP Batch Release: Automated, audit-ready constant weight for routine batch release testing.

Food & Beverage Industry

Food Contact Materials: Total migration testing per GB 31604 series and EU Framework Regulation.

Moisture & Solids Determination: Nutritional labeling support per AOAC/ISO methods.

Bottled Water & Beverages: Quality control per GB 8538 and ISO 7887.

Shelf-Life Studies: Accelerated stability testing for formulation optimization.

Chemicals & New Materials

Polymer Non-Volatile Residue: Determine solids content in resins, adhesives, and coatings.

Raw Material Incoming Inspection: Verify supplier certificates of analysis.

R&D Formulation: Screen drying parameters for new product development.

Third-Party Testing & Research Institutes

CNAS/CMA-Compliant Services: Issue legally defensible reports referencing USP, EP, or ISO standards.

Contract Research (CRO): High-throughput sample analysis for pharmaceutical clients.

Method Development: Validate in-house procedures against official pharmacopoeia methods.

Frequently Asked Questions (FAQ)

Q1: How does the ETR Series replace traditional lab workflows?

A: It consolidates water bath evaporation, drying oven, desiccator cooling, and analytical weighing into a single automated system. This eliminates manual sample transfers between instruments, reduces human error, shortens testing cycles from days to hours, and improves reproducibility.

Q2: Is the instrument suitable for GMP and pharmacopoeia-regulated labs?

A: Yes. The ETR Series is engineered for regulated environments and complies with USP <921>, EP 2.2.32, and ChP loss-on-drying requirements. When equipped with the optional GMP module, it satisfies FDA 21 CFR Part 11 requirements for electronic records and signatures.

Q3: Why is the patented balance protection important?

A: Traditional balances degrade quickly when exposed to heat and humidity during drying processes. Our patented insulation, moisture-proof, and anti-corrosion design isolates the balance from harsh conditions, preserving 0.1 mg (or 0.01 mg) accuracy and significantly extending service life.

Q4: Which model should I choose?

A: Select based on throughput needs:

ERT-231-B (23 stations): Ideal for QC labs with moderate daily workloads.

ERT-462-B (46 stations): Best for high-volume testing, contract labs, and production environments.

Custom 12–69 workstation configurations are also available upon request.

Q5: Is the solvent recovery option worthwhile?

A: Highly recommended. Recovering up to 95% of solvents sharply reduces hazardous waste disposal costs and lowers VOC emissions, delivering strong economic and environmental benefits for labs processing large numbers of samples.

Q6: Can the system handle food-contact-material migration testing?

A: Yes. The ETR Series fully supports GB 31604.8 and related international standards for total migration and residue determination in food packaging materials.

Q7: What balance is included, and can it be upgraded?

A: The standard configuration includes a METTLER TOLEDO analytical balance (210 g capacity, 0.1 mg readability). For ultra-trace applications, a 0.01 mg readability upgrade is available as an option.

Functions
Constant weight tests for loss on drying, non - volatile substances, residue quantity, total migration, volatile substances, moisture content, soluble and insoluble quantities.
It can replace water baths, drying ovens and balances to achieve constant weight .
Standards:
Constant weighting requirement in Chinese Pharmacopoeia, Extractives Determination Method" in Part Four of the Chinese Pharmacopoeia、Loss on Drying Determination Method、Total Solids Determination Method、USP40-NF35<921>、YBB 00342002、YBB00132002、GB 31604.8、GB5009.3、GB 8538、DZT0064.9、GBT14415、GBT5750.4、GB/T 9740、GB/T2914、GB5413.39、ISO 759、"Purified Water" in Part Two of the Chinese Pharmacopoeia、EP9.0 WATER, PURIFIED
Features
- Complies with national standards and features a fully automated four-process system: water bath, drying, cooling, and weighing.
- Precise and efficient: Achieves 0.3mg constant weight with just 2 drying cycles. Available with 12、18, 23, 33, 46, or 69 workstations.
- Safe: Indirect heating design to prevent combustion and explosion. Equipped with over temperature power off protection and water level protection.
- Compact: Water bath chamber, drying oven, cooling unit and weighing balance are integrated into one unit, footprint reduction.
- Features patented: heat insulation, moisture proof, and anti-corrosion technology for the balance, ensuring its stability and long service life.
- Digitally set test parameters, fully automated operation without manual intervention. Offers two test modes: constant weight and constant time.
- Equipped with METTLER TOLEDO balance.
- Software: Provides graphical, full process and all element monitoring, along with multiple report formats.
- Optional: GMP "Computerized System" functional module.
- Optional: High - efficiency solvent recovery device.

Specification

Name	Parameter	Name		Parameter
Constant Weighting Error	0.3 mg （2 heating cycles）	Residue Range		0～80 g
Balance Range	210 g	Balance resolution		0.1 mg
Temperature Error	0.5 ℃	Evaporating Temperature		Room Temperature ～100 ℃
Drying Temperature	Room Temperature～140 ℃	Weighing Temperature		room～80 ℃
Evaporite Mode	Water bath	Weighing humidity		＜20%
Evaporating utensil capacity	100 mL (Optional: 50, 200 mL)	Connect Pipe		Φ8 mm
Air Pressure	>0.3 MPa	Solvent Recovery Rate		95% (Optional: Solvent Recovery Machine)
Power Supply	AC220V /110V ;50/60Hz
Model	Model
	ERT-231-B		ERT-462-B
Specimen Count	23		46
Balance Count	1		2
Size (L×B×H) mm	1300x870x1160 mm
Net Weight	~175kg		~185kg
Power Consumption	<10,000 W

Keywords:

Dynamic Vapor Sorption Analyzer - DVS Wetability Tester

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